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meropenem side effects in cats

1. General Description: Meropenem. Therefore, inform your veterinarian of any and all medications your pet may be taking. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. Meropenem. Diarrhea. Headache 5. Medically reviewed by Drugs.com. amoxicillin, Keflex, doxycycline, triamcinolone, metronidazole, azithromycin, ciprofloxacin, clindamycin, Augmentin, Flagyl. However, many people have no side effects or only have minor side effects. Meropenem has been reported to be excreted in human milk. One of the adverse effects caused from imipenem therapy is seizures. Wiseman LR, Wagstaff AJ, Brogden RN, Bryson HM. 2018 Jul 1;73(7):1908-1916. doi: 10.1093/jac/dky128. Available for Android and iOS devices. Learn about the prescription drug meropenem (Merrem) used to treat a variety of bacterial infections. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Zeneca Pharmaceuticals, Wilmington, DE. Along with its needed effects, meropenem may cause some unwanted effects. "Comparative Review of the Carbapenems." J Antimicrob Chemother 36(suppl a (1995): 121-33, 18. US Brand Name. The pharmacokinetic parameter … Meropenem, one of the newest of the carbapenem class of drugs has antibacterial activity approximately equal to, or greater than imipenem. Bluish lips or skin 2. chills 3. cold, clammy skin 4. confusion 5. dizziness 6. fainting 7. fast heartbeat 8. fast, weak pulse 9. fever 10. itching, skin rash 11. lightheadedness 12. rapid, shallow breathing 13. sweating Development of a physiologically-based pharmacokinetic pediatric brain model for prediction of cerebrospinal fluid drug concentrations and the influence of meningitis. Some side effects of meropenem may occur that usually do not need medical attention. J01DH02 - meropenem ; Belongs to the class of carbapenems. J Antimicrob Chemother 36(suppl a (1995): 179-89, 16. All drugs may cause side effects. Meropenem reduces plasma valproate concentrations, affording two mechanisms for an increased risk of seizures in patients with epilepsy, epileptogenic effect of meropenem, and loss of antiepileptic action of valproate [46A,47A,48A,49A,50A,51A,52c]. Hemsell DL, Martens MG, Faro S, Gall S, Mcgregor JA "A multicenter study comparing intravenous meropenem with clindamycin plus gentamicin for the treatment of acute gynecologic and obstetric pelvic infections in hospitalized women." 1995 Jul;50(1):73-101. doi: 10.2165/00003495-199550010-00007. Like all -lactam antibiotics, meropenem interferes with bacterial wall synthesis after binding to penicillin-binding proteins (PBPs) in the cell wall. This drug is ototoxic and nephrotoxic. This medicine helps most people with infections, but it may have unwanted side effects in a few people. 2. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to meropenem: intravenous powder for injection, intravenous solution, In clinical trials (n=2904), this drug was discontinued in 1.2% of patients due to side effects; 5 deaths were possibly drug-related. Drugs 67 (2007): 1027-1052, 4. Merrem IV; Descriptions. Rev Infect Dis. Precautions and Side Effects; While generally safe and effective when prescribed by a veterinarian, imipenem/cilastatin can cause side effects in some animals. Last updated on Jul 26, 2020. Ask Your Own Veterinary Question. Embil JM, Soto NE, Melnick DA "A post hoc subgroup analysis of meropenem versus imipenem/cilastatin in a multicenter, double-blind, randomized study of complicated skin and skin-structure infections in patients with diabetes mellitus." infections in cystic fibrosis patients." General Description: Meropenem. Get the latest research from NIH: https://www.nih.gov/coronavirus. 1. Applies to meropenem: intravenous powder for solution. What are some other side effects of Meropenem? Veterinarian: Dr. Susan, Veterinarian replied 9 years ago. is supplied in 20 mL and 30 mL injection vials containing sufficient meropenem to deliver 500 mg or 1 g, respectively. These side effects may go away during treatment as your body adjusts to the medicine. Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR "Pharmacokinetics of meropenem compared to imipenem-cilastatin in young, healthy males." 2016. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Seizures and other adverse CNS experiences have been reported. Bax RP, Bastain W, Featherstone A, Wilkinson DM, Hutchison M, Haworth SJ "The pharmacokinetics of meropenem in volunteers." Meropenem (Meropenem Hikma®; Hikma Pharma, Gräfelfing, Germany) was administered as a prolonged infusion over 4 h using a syringe pump. Eur J Clin Microbiol Infect Dis 10 (1991): 85-8, 13. O 0, 14. has been prescribed for your pet for the treatment of an infection caused by susceptible bacteria because other less expensive antibiotics were not effective or unacceptable because of their adverse effects. Cats Label dose: 10-15mg/kg PO or IV q12h: For serious anaerobic infections: 25 – 50 mg/kg PO or IV q12h: For enteritis caused by Clostridium difficile: 62.5mg/cat PO q12h for 5d: For metronidazole benzoate: 25 mg/kg PO q12h : Dogs Label dose: 10-15mg/kg PO q12h: Brand Name(s) Flagyl® Background. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. In case of any doubt consult your doctor or pharmacist. Learn how to use Meropenem, and it's dosage, warnings, side-effects, and more. You may need medical attention if you get some of the side effects. Clipboard, Search History, and several other advanced features are temporarily unavailable. Clin Infect Dis. O 0, 3. doi: 10.1093/clinids/24.supplement_2.s266. It inhibits bacterial cell wall synthesis by binding to several penicillin-binding proteins (PBPs) in gram-negative and gram-positive bacteria resulting in cell wall assembly arrest and eventually bacterial cell lysis. Meropenem may also interact with some other medications. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. Adverse Side Effects. The IV LD50 of meropenem in rodents is greater than 2000 mg/kg. Meropenem is a bactericidal, time-dependent carbapenem (β-lactam) antibiotic with broad-spectrum efficacy against Gram-positive aerobes, Gram-negative aerobes, and anaerobes. Three dogs were excluded from the age count because of an unknown birth date. Find patient medical information for Meropenem Intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Eur J Drug Metab Pharmacokinet. Please enable it to take advantage of the complete set of features! Anemia If experienced, these tend to have a Less Severe expression 1. Drugs. Ralph ED, John M, Rieder MJ, Bombassaro AM "Serum Sickness-like Reaction Possibly Associated with Meropenem Use." J Antimicrob Chemother 24(suppl a (1989): 311-20, 12. Predictive Performance of Physiologically Based Pharmacokinetic and Population Pharmacokinetic Modeling of Renally Cleared Drugs in Children. Precautions Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to other carbapenems (such as imipenem); or to penicillins or cephalosporins; or if you have any other allergies. Therapeutic uses, prescribing information and product availability may vary between countries. Constipation 3. It is the same drug class as Imipenem. Meropenem is generally well tolerated by the central nervous system. Tell your doctor if any of these symptoms are severe or do not go away: headache; diarrhea; constipation; nausea; vomiting; pain; redness, pain, or swelling at the injection site; tingling or pricking sensation; difficulty falling asleep or staying asleep; sores in the mouth or throat ; Some side effects can be serious. Shah PM, Heller A, Fuhr HG, Walther F, Halir S, Schaumann R, Bohme A, Jung B, Kohler A, Lipsschulte C, Stille W "Empirical monotherapy with meropenem versus imipenem/cilastatin for febrile episodes in neutropenic patients." Meropenem (Merrem) use in cats, is it safe? Sometimes they are serious, most of the time they are not. Upset stomach or throwing up. The concentration of meropenem in breast milk was evaluated in a study of a 41-year-old woman treated for a postpartum urinary tract infection caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli with meropenem 1 g IV q 8 h. Dr. Susan, Veterinarian. This is especially important if your pet is currently taking probenecid. Clin Ther 28 (2006): 1164-74, 6. Many Enterobacteriaceaethat are resistant to other antimicrobials will be susceptible to meropenem; therefore, use should be strictly reserved for infections caused by organisms that are resistant to other antimicrobial choices. In repeat dose studies of up to 6 months duration only minor effects were seen including a decrease in red cell parameters in dogs. Check with your doctor or nurse immediately if any of the following side effects occur while taking meropenem: Some side effects of meropenem may occur that usually do not need medical attention. 1995 Apr;28(4):275-86. doi: 10.2165/00003088-199528040-00002. Clinical Application of Pharmacokinetics: Basis for Rational Dose Selection in a Critically Ill Patient on Renal Replacement Therapy. Answered in 15 minutes by: 12/5/2010. Side effects not requiring immediate medical attention. Meropenem Study Group." 1997 Feb;24 Suppl 2:S266-75. However, clinical trials are necessary to confirm clinical efficacy of the proposed dosage regimen. [Ref], Common (1% to 10%): Pain, inflammation, sepsis/septicemia, shock, accidental injury, Uncommon (0.1% to 1%): Chest pain, fever, back pain, chills, pelvic pain, peripheral edema, abdominal enlargement[Ref], Common (1% to 10%): Inflammation at the injection site, phlebitis/thrombophlebitis, pain at the injection site, Uncommon (0.1% to 1%): Injection site reactions, edema at the injection site[Ref], Common (1% to 10%): Rash (including diaper/nappy area moniliasis), pruritus, Uncommon (0.1% to 1%): Urticaria, sweating, skin ulcer, Postmarketing reports: Toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme, severe skin reactions[Ref], Common (1% to 10%): Apnea, pharyngitis, pneumonia, Uncommon (0.1% to 1%): Respiratory disorder, dyspnea, pleural effusion, asthma, increased cough, hypoxia, lung edema, Frequency not reported: Respiratory failure[Ref], Heart failure occurred more often in patients with moderately severe renal dysfunction. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. If you notice any behavioral or physiological side effects when administering this medication, contact your veterinarian immediately. Meropenem, when administered to cats at a dose of 10 mg/kg q12h,, is effective against bacteria with MIC values of 6 μg/ml, 7 μg/ml and 10 μg/ml for IV, IM and SC administration, respectively. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. COPD Study Group." Tell your doctor as soon as possible if you do not feel well while you are receiving meropenem. Cerner Multum, Inc. "UK Summary of Product Characteristics." doi: 10.1093/clinids/24.supplement_2.s249. Meropenem resists the actions of many enzymes that degrade most other penicillins and penicillin-like anti-infectives. Seizures occurred more often in patients with moderately severe renal dysfunction. [Ref], Common (1% to 10%): Anemia, hypochromic anemia, bleeding events (including gastrointestinal hemorrhage, melena, epistaxis, hemoperitoneum), thrombocythemia, Uncommon (0.1% to 1%): Increased platelets, increased eosinophils, decreased platelets, decreased hemoglobin, decreased hematocrit, decreased white blood cells, decreased prothrombin time, decreased partial thromboplastin time, leukocytosis, eosinophilia, thrombocytopenia, leukopenia, neutropenia, Postmarketing reports: Agranulocytosis, positive Coombs test (direct or indirect), hemolytic anemia[Ref], Shock occurred more often in patients with moderately severe renal dysfunction. Sign up now. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.  |  Huizinga WK, Warren BL, Baker LW, Valleur P, Pezet DM, Hoogkamp-Korstanjep JA, Karran SJ "Antibiotic monotherapy with meropenem in the surgical management of intra-abdominal infections." eCollection 2019. Meropenem. This site needs JavaScript to work properly. Share this conversation. A Skin Rash 2. Effects were seen in acute toxicity studies in rodent at doses exceeding 1000 mg/kg. Get the latest public health information from CDC: https://www.coronavirus.gov. Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies. J Antimicrob Chemother 36(suppl a (1995): 135-43, 17. Although not all of these side effects may occur, if they do occur they may need medical attention. Crit Care Med 30 (2002): 2580-3, 20. Clin Infect Dis 36 (2003): E149-E151. Free E-newsletter Subscribe to Housecall. "Product Information. If experienced, these tend to have a Severe expression 1. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. In a review of 4872 patients, diarrhea, rash, nausea/vomiting, injection site inflammation, thrombocytosis and increased hepatic enzymes were reported most often. Some side effects may not be reported. Its advantage over imipenem is that it is more soluble and can be administered in less fluid volume and more rapidly. 1991 Feb;10(2):85-8. doi: 10.1007/BF01964413. Description and Brand Names. The urinary recovery of meropenem is as high as that of imipenem in combination with cilastatin, an inhibitor of renal dehydropeptidase. Animal ages ranged from 0 to 19 years of age, with a median of 11 years. Meropenem. Imipenem should not be used in animals with known hypersensitivity or allergy to the drug or other beta-lactams. Merrem (meropenem)." Vomiting No information is available on the effects of meropenem on the breast-fed child or on milk production. Adequate and well-controlled studies of this drug in pregnant women are lacking, and this drug should be used during pregnancy only if clearly needed.  |  2019 Jun 13;15(6):e1007117. Meropenem is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Drugs 68 (2008): 803-38, 5. Side effects. NIH Clin Infect Dis 24 ( Suppl (1997): s222-30, 9. Recommend consultation with a urinary or infectious disease veterinary specialist or veterinary pharmacologist prior to use. Common side effects include nausea, diarrhea, constipation, headache, rash, and pain at the site of injection. Meropenem injection is used to treat infections caused by bacteria. [Ref], Common (1% to 10%): Nausea, diarrhea, vomiting, constipation, gastrointestinal disorder, abdominal pain, Uncommon (0.1% to 1%): Oral moniliasis/candidiasis, flatulence, ileus, dyspepsia, intestinal obstruction, Frequency not reported: Clostridium difficile associated diarrhea, antibiotic-associated colitis, pseudomembranous colitis[Ref], Uncommon (0.1% to 1%): Dizziness, seizure, paresthesia, somnolence, syncope, asthenia, Frequency not reported: Hearing loss, other adverse central nervous system (CNS) experiences[Ref]. Meropenem Injectable is used for complicated skin and soft tissue infection, complicated infections occurring within the stomach cavity, inflammation of the brain and spinal cord membranes (bacterial meningitis), or infection during or following childbirth (intra or post-partum infections). Nilsson-Ehle I, Hutchison M, Haworth SJ, Norrby SR. Eur J Clin Microbiol Infect Dis. Zhou W, Johnson TN, Xu H, Cheung S, Bui KH, Li J, Al-Huniti N, Zhou D. CPT Pharmacometrics Syst Pharmacol. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. CPT Pharmacometrics Syst Pharmacol. Normalement, c'est un médecin ou une infirmière qui vous administrera MEROPENEM MYLAN 1 g, poudre pour solution injectable/pour perfusion. Clin Pharmacokinet. All medicines can have side effects. These side effects may go away during treatment as your body adjusts to the medicine. Approximately 70% of meropenem is excreted via the kidneys, thus dosage adjustments are required for patients with renal impairment. We comply with the HONcode standard for trustworthy health information -, unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness, vomiting of blood or material that looks like coffee grounds, white patches in the mouth, tongue, or throat, blistering, peeling, or loosening of the skin, holding false beliefs that cannot be changed by fact, large, hive-like swelling on the face, eyelids, tongue, throat, hands, legs, feet, or genitals, red skin lesions, often with a purple center, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots in the mouth or on the lips, unusual excitement, nervousness, or restlessness, redness and swelling at the injection site, redness, swelling, or soreness of the tongue, excess air or gas in the stomach or bowels. Hamacher J, Vogel F, Lichey J, Kohl FV, Diwok K, Wendel H, Lode H "Treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease in hospitalised patients--a comparison of meropenem and imipenem/cilastatin. Amikacin can be stored at room temperature and is stable for up to 2 years. HHS Am J Health Syst Pharm 69 (2012): 1109, 19. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy. Cats are very susceptible to the vestibular effects of amikacin. Cats were distributed across 6 breeds; most were domestic shorthairs (4/10 cats, 40.0%). The median age of dogs was 10 years (range, 1‐14), and the median age of cats was 13 years (range, 0‐19). J Antimicrob Chemother. NLM Read the side effects of Meropenem as described in the medical literature. 2019 Nov 19;2019:1368397. doi: 10.1155/2019/1368397. Diarrhea 4. Category: Veterinary. Plasma and Renal Cortex Meropenem Concentrations in Patients Undergoing Percutaneous Renal Biopsy. Meropenem is a carbapenem antibiotic that appears to be widely distributed in tissues and is eliminated by both excretion and metabolism. Mouton YJ, Beuscart C "Empirical monotherapy with meropenem in serious bacterial infections. [Ref], Common (1% to 10%): Peripheral vascular disorder, Uncommon (0.1% to 1%): Heart failure, heart arrest, tachycardia, hypertension, myocardial infarction, pulmonary embolus, bradycardia, hypotension[Ref], Common (1% to 10%): Increased transaminases, Uncommon (0.1% to 1%): Increased AST, increased ALT, increased bilirubin, hepatic failure, cholestatic jaundice/jaundice[Ref], Common (1% to 10%): Hypoglycemia, increased alkaline phosphatase, increased lactate dehydrogenase, Uncommon (0.1% to 1%): Anorexia, hypervolemia, hypokalemia[Ref], Uncommon (0.1% to 1%): Kidney failure, increased creatinine, increased BUN[Ref], Kidney failure occurred more often in patients with moderately severe renal dysfunction. Antimicrob Agents Chemother 42 (1998): 1233-8, 8. [Ref], Uncommon (0.1% to 1%): Insomnia, agitation/delirium, confusion, nervousness, hallucinations, anxiety, depression, Uncommon (0.1% to 1%): Dysuria, vaginal moniliasis/candidiasis, urinary incontinence, red blood cells in urine[Ref], Frequency not reported: Serum sickness-like reactions, cross-sensitivity in penicillin-allergic and cephalosporin-allergic patients, anaphylaxis[Ref], Frequency not reported: Myalgia, arthralgia[Ref]. PLoS Comput Biol. Infection 24 (1996): 480-4, 10. The safety of imipenem/cilastatin has not been established for animals that are pregnant or lactating. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. COVID-19 is an emerging, rapidly evolving situation. They have occurred most commonly in patients with CNS disorders (e.g., history of seizures, brain lesions) or with bacterial meningitis and/or renal dysfunction.

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